Furosemide-associated nephrocalcinosis and renal cysts

Medullary Nephrocalcinosis in a Furosemide Abuser

A 31-year-old woman with a long history of furosemide abuse presented with abdominal pain. She had been using furosemide (>200 mg per day) for at least the last 15 years. She initially used furosemide to maintain her urinary volume and later for weight loss. Her abdominal pain was caused by paralytic ileus due to hypokalemia (2.1 mEq/L). Although abdominal and pelvic CT revealed no intestinal o...

Hereditary xanthinuria type II associated with mental delay, autism, cortical renal cysts, nephrocalcinosis, osteopenia, and hair and teeth defects.

R Zannolli, V Micheli, M A Mazzei, P Sacco, P Piomboni, E Bruni, C Miracco, M M de Santi, P Terrosi Vagnoli, L Volterrani, L Pellegrini, W Livi, B Lucani, S Gonnelli, A B Burlina, G Jacomelli, F Macucci, L Pucci, M Fimiani, J A Swift, M Zappella, G Morgese . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Renal hypomagnesemia, hypercalciuria, nephrocalcinosis

Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme

BACKGROUND Chronic hypokalemia is known to induce renal structural and functional abnormality. The former includes induction of renal cyst formation and interstitial fibrosis while the latter entails urine-concentrating defect. However, these hypokalemia-mediated changes occur in a handful of conditions including primary aldosteronism, distal renal tubular acidosis, Liddle's disease, apparent m...

Complex renal cysts associated with crizotinib treatment

An apparent causal association between crizotinib treatment and renal cyst development emerged during clinical trials in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Serious adverse event (SAE) reports of renal cysts from a safety database of 1375 patients from four clinical trials were reviewed. A blinded, retrospective, independent radiologic review (IRR) was ...